What Was the U.S. POINTER Trial?

A large U.S. study of 2,000 older adults (ages 60–79) who were at higher risk for memory problems, but did not yet have dementia.

The goal: see if healthy lifestyle changes can help keep memory and thinking sharp.

What Did They Do?

People were placed into two groups for 2 years: 

Structured Program (more hands-on)

• Regular meetings with coaches
• Help setting goals and staying accountable
• Group exercise sessions, healthy meal guidance, brain games, and social activities

Self-Guided Program (more on your own)

• Received health information and general advice
• Fewer check-ins, less structured support

What Did They Find?

Both groups improved in memory and thinking, but…

• The structured program helped people do a little better than the self-guided group.
• People with lower starting memory scores seemed to benefit the most.
• The program worked well for all types of people — including those with genetic risks.
• Benefits were seen across risk groups (e.g., genetics, demographics).
• Fewer health problems (like falls or medical events) were reported in the structured group.

What Improved—And What Didn’t

• Executive function (skills like planning, decision-making, and focusing) showed the clearest benefit: the structured group had better improvement than the self-guided group by 0.037 SD per year.

• Memory and Processing Speed didn’t show significant differences between the groups.

• So, structured support seemed especially helpful for tasks that involve organizing, staying focused, and thinking clearly—not necessarily remembering lists or doing things faster.

Key parts of a brain-healthy routine:

• Regular physical activity

• Nutritious diet

• Social connection

• Brain exercises and learning

• Managing blood pressure, diabetes, and cholesterol

What Was This Study About?

Instead of using just one drug or treatment for everyone, this study tested a personalized medical plan—a “precision medicine” approach—for people with mild memory problems or early dementia due to Alzheimer’s. Each person was tested for different health factors that might affect their memory—such as inflammation, infections, poor blood sugar control, hormone issues, nutrient deficiencies, and toxin exposures—and then received a tailored treatment plan addressing those issues

Who Took Part?

• 25 adults, aged 50 to 76, with mild cognitive impairment or early Alzheimer’s.

• All participants had fairly decent thinking scores at the start (MoCA score ≥19). 

What Happened During the Study?

Health Testing:

• Participants were tested for a range of things—including inflammation and blood sugar issues, possible toxins, hormone levels, nutrition, and sleep breathing problems.

Personalized Plans:

• Each person followed a medically guided, individualized plan for 9 months.

Check-Ins at 3, 6, and 9 Months

• Their thinking and memory were assessed several times during the study. Everyone completed the full 9-month program.

What were the benefits and risks?

• Thinking and memory scores improved: Tests like the MoCA, the CNS Vital Signs test, and the Alzheimer’s Questionnaire showed statistically significant improvement. 

• Brain imaging looked better: MRI scans showed improvements in brain volumes (less loss), suggesting better brain health.

• No serious side effects: The program appeared safe—no one experienced serious problems related to the interventions.

What Did the Study Do?

Doctors wanted to see if making very healthy lifestyle changes could help people with mild memory problems or early Alzheimer’s disease. They compared two groups:

• One group followed an intensive “healthy living” plan—eating a plant-based diet, exercising, doing stress-management, and joining group support sessions.

• The other group continued their usual habits for 20 weeks, without making these changes.

Who Took Part?

• 51 people with mild cognitive impairment or early-stage Alzheimer’s, average age about 73 years.

• Most stayed with the study—only two people dropped out

What Happened After 20 Weeks?

Better Thinking & Daily Abilities

• On several standard tests, included global clinician impressions and memory/function ratings, the healthy-living group improved or stayed steady, while the usual-care group got worse. One test of thinking showed nearly significant improvement. 

​​​​​​Biological Signs Improved

• Blood markers related to Alzheimer’s (like the Aβ42/40 ratio) went up in the intervention group and down in the usual-care group. 
• Gut bacteria (“microbiome”) also improved only in the healthy-living group. 

Greater Effort, Greater Gain

• The more closely participants followed the plan (diet, exercise, stress relief, support groups), the more they improved on both cognitive tests and biomarkers.

A Few Important Things to Know

Study size was small (51 people), which limits how broadly we can apply the results.

Blinding was not possible—participants knew if they were making lifestyle changes, which could affect outcomes. 

Short duration (20 weeks). Longer studies are needed to see if the benefits last. 

Not everyone improved. In the lifestyle group: some improved, some stayed the same, some worsened.  A big reason seemed to be how well they followed the program.